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A unique, integrated collection of original contributions on the molecular biology, physiology, and pathology of endothelin. Leading academic, clinical, and industrial researchers summarize the dramatic recent progress in endothelin research and indicate the optimal direction of future studies. The contributors produce a critical evaluation of endothelin chemistry and pharmacology, its mechanism of action, and its physiological functions. The book is certain to become the new standard reference source for both basic scientists and informed clinicians who want a clear idea of the roles endothelin may play in cardiovascular physiology and pathology.In Endothelin: Molecular Biology, Physiology, and Pathology, academic, clinical, and industrial researchers summarize the dramatic recent progress that has been documented in endothelin research and indicate the optimal direction of future studies. The contributors, highly respected authorities in their fields as well as active bench scientists, produce a critical evaluation and synthesis of our knowledge of endothelin chemistry and pharmacology, its mechanism of action, and its physiological functions. §Endothelin: Molecular Biology, Physiology, and Pathology is certain to become the new standard reference source for both basic scientists and informed clinicians who want a clear idea of the roles endothelin may play in cardiovascular physiology and pathology. Biochemists, as well as medicinal and clinical chemists, involved in the development of drugs designed to alter the action or expression of the endothelin molecule will find the book rich in new results and insights.§[